Integrating the STEM method within the Education 5.0 framework can markedly improve 21st-century skills in high school pupils by unifying science, technology, engineering, and mathematics into a comprehensive learning plan. This study systematically reviews how STEM education within Education 5.0 frameworks specifically improves digital literacy, creativity, and collaboration skills in high school students. The novelty of this research lies in the integration of three crucial concepts that have never been comprehensively researched: STEM, Education 5.0, and 21st-century skills. The research employs a systematic review methodology, analyzing existing literature to identify effective practices and outcomes associated with STEM education. The findings will demonstrate how STEM education enhances academic performance but also fosters creativity and innovation among students. By engaging in project-based learning and collaborative activities, students are better equipped to tackle real-world challenges, thus preparing them for future careers in a technology-driven environment. The conclusion reinforces the transformative potential of STEM education in preparing students for the demands of the 21st century while addressing the challenges and disparities that exist within educational systems. Future research should focus on developing innovative assessment tools that measure transdisciplinary learning and critical thinking skills, moving beyond traditional standardized testing methods. © 2025 the author(s), published by De Gruyter, Berlin/Boston.
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