Low critical thinking skills are a crucial problem in science learning. Meanwhile, the purpose of this research was to determine the effect of the i-Spring Suite 10 media on students’ critical thinking skills in natural science. The research method used a quasi-experimental with a limited population, namely 6th-grade elementary students. The sample was selected using a purposive sampling technique. Thus, two classes were used as samples, namely 6th A grade with 20 students and 6th B grade with 20 students. The 6th A grade as an experimental class and used interactive multimedia based on i-Spring Suite 10. Meanwhile, 6th B grade was the control class and used audiovisual-based multimedia. The research instrument used a test with multiple choices and explanations. Based on the results of statistical analysis, the results of t<inf>observed</inf> were 2.89 and t<inf>critical</inf> with a significance level of 5% (ɑ = 0.05) of 2.025. From these results, it was found that t<inf>observed</inf> > t<inf>critical</inf>. This study concludes that there is a significant effect of the interactive multimedia based on i-Spring Suite 10 on students’ critical thinking skills in natural science subjects. © 2023, author.
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