One Health is an emerging area of integrative studies and interventions aimed at preventing zoonotic diseases by addressing human, animal, and environmental interactions. A fundamental aspect of the concept is understanding how these interactions influence health outcomes among humans, animals, and ecosystems. Developed initially to respond to the need for more human and veterinary medicine collaboration, One Health must include social and environmental dimensions and biomedicine to establish a biomedical-integrative system. A comprehensive approach must also be applied to the research's social, biological, historical, and local aspects. With One Health, health-related disciplines can be reconciled, and its transdisciplinary imperative will provide solutions to the limitations of current biomedical and public health principles. This article aims to discuss and define zoonoses in different sectors. Accordingly, it calls for developing an international priority-setting framework to monitor, report, and assess zoonoses following their relative health conditions in epidemic, endemic, and pandemic settings. Current models of global health governance in pandemic prevention still face challenges, such as policy incoherence, response delays, and inequity in resource access. International coordination, investment in surveillance systems, and promotion of information transparency are key strategies for improving health crisis management. Accordingly, it is suggested that member states of international organizations participate more actively in establishing cooperation frameworks and develop more effective implementation mechanisms for managing emerging health threats. To safeguard global health security, policymakers, researchers, and public health officials will find insights, recommendations, and actionable strategies in this article. © 2025 The Author(s). Public Health Challenges published by John Wiley & Sons Ltd.
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